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ChIP-qPCR assays performed using an anti-BRD4 antibody revealed a markedly higher enrichment of BRD4 at PGK1 and VIM promoters in GFP-ASXL1 1-645 -WT expressing cells compared to the enrichment of BRD4 in GFP-ASXL1 1-645 -I574D expressing cells, indicating the ASXL1 EBM -dependent recruitment of BRD4 (Fig

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Curr Pharm Des 14(11):11131123 Frederiksen LJ, Sullivan R, Maxwell LR, Macdonald-Goodfellow SK, Adams MA, Bennett BM, Siemens DR, Graham CH (2007) Chemosensitization of cancer in vitro and in vivo by nitric oxide signaling